The Giants were knocked out of the BBL Cup at the first hurdle as they fell to their fourth defeat of the new season.
Yorick Williams' men held their own in the first quarter against the visiting Nix, staying within three points of their visitors.
They went into the second period 23-20 down but fell further behind at 53-36 down by half-time.
More problems in the third quarter saw them go into the final quarter 76-52 down and despite something of a rally, a comeback never came.
Williams led the way himself with 19 points in 30 minutes while Callum Jones had 18, Jerelle Okoro 15 and big man Donatas Visockis 11.
The Lithuanian also took eight rebounds and showed some neat passing touches as one of the Giants' positives.
Jamelle Anderson led the visitors' effort with a game-high 25.
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