The Giants went down to a disappointing defeat in the final game of the season.
After Bristol beat Leeds on Saturday, it was not possible for the Giants to qualify for the play-offs.
And a fired-up and talented London team git the better of the contest at the Trafford Sportsdome.
After taking the first quarter 27-24 they broke the game open in the second and had a 6-412 half-time lead.
The maintained their advantage at 80-61 at the end of the third and cruised to the win.
Stefan Gill (pictured) led the Giants with 19 points while Devin Grimes had 17 and Rob Marsden scored 15 and took 7 boards.
Andrew Sullivan had a game-high 20 for the Lions.