The Giants endured a tough night in Sheffield.
After winning on the road in London last time out, Yorick Williams men found the Sharks a tough nut to crack on their own court.
Big man TJ Robinson was hard to handle, scoring a game-high 24 and taking 13 rebounds.
The Giants fought hard but went 26-15 down in the first quarter and by 47-31 by half-time.
The Sharks went into the fourth period 75-51 and the gap proved too wide.
Ingus Bankevics and Callum Jones (above) hit 14 points apiece for the Giants.